FlexSim

A discrete-event simulation package with the capability to simulate assets such as human workers, AMRs, AGVs and robotic arms

Simpy

A library for discrete-event simulation of operations in Python

CoppeliaSim

A software package for Physics simulation of small robotic systems including manipulation and navigation

Nvidia IsaacSim

A comprehensive scalable framework for simulation of robotic systems by NVIDIA

Google OR-Tools

A very strong optimization library by Google specifically useful forsolving multi-vehicle routing problems

Gurobi

A popular library for optimization and operation research